Prevention and control: strengthen feeding management, regular disinfection, strict epidemic prevention and immunization. Common vaccines for vaccination include live attenuated vaccines and inactivated vaccines. Appropriate immunization procedures for respiratory or renal chicken infectious bronchitis should be formulated according to the local epidemic situation, and vaccinated according to the vaccination instructions. Infectious bronchitis H120 attenuated strain was first immunized in chickens from 7 to 10 days of age, second immunization with highly virulent infectious bronchitis H52 attenuated strain at about 1 month of age, and second immunization with H52 attenuated strain at 120 to 140 days of age. In areas where infectious bronchitis of kidney type occurs seriously, the live vaccine or inactivated vaccine prepared by infectious bronchitis virus strain of kidney type chicken can obtain better immune effect. At present, there is no specific drug, the sick chickens should be isolated from the sick chickens in chicken farms, and the sick chickens should be treated in a timely and harmless manner. At the same time, strengthening feeding management and sanitary disinfection, reducing stress factors, adding antiviral and antimicrobial drugs in feed or drinking water, adding multi-vitamins and trace elements, can reduce the mortality of the disease. Compound oral rehydration salts or compound preparations containing citrate or bicarbonate can be used to eliminate kidney inflammation. Diuretics can promote the excretion of uric acid and make sick chickens recover as soon as possible.